发给老马备查:
+ O4 Q/ |7 z/ Z! e, K, N滴水察海(69304838) 15:23:23
& ]! a' t! x* E( I4 \老马,我看到培美和S-1都提到TS低表达,而鳞多半不是低表达,是不是S-1不靠谱/ [! e0 w( F8 n" Z, ^' O
吉非替尼和S-1连用的依据
& g/ v0 w8 I: q1 L4 _# I- BGefitinib induced down-regulation of thymidylate synthase and E2F-1 in gefitinib-resistant NSCLC cells with MET amplification but not in those harboring the T790M mutation of EGFR. The combination of 5-fluorouracil and gefitinib synergistically inhibited the proliferation of cells with MET amplification, but not that of those with the T790M mutation of EGFR, in vitro.
: Z, U9 @4 s6 s+ B是不是说因C-MET引起的耐药中,吉非替尼会引导TS低表达: T# E* N3 I0 }( w* Y# g
这样是不是推理出,耐药后,可以用S-1和培美了?+ n8 P7 l' z! w0 W6 @6 `2 K8 t
结论:
6 c* ?) q# R! P# x如果是T790M突变引起的耐药,则2992有效,如果是C-MET扩增引起的突变,则除了184,还可以特+S1联用,而且可能可以用培美。 |