发给老马备查:- G9 o$ T" A0 J
滴水察海(69304838) 15:23:23) m( Q! B2 _0 P7 v" q
老马,我看到培美和S-1都提到TS低表达,而鳞多半不是低表达,是不是S-1不靠谱
9 a, a6 K4 Y- ?" r% |吉非替尼和S-1连用的依据
/ L- R% e- r$ Z4 hGefitinib induced down-regulation of thymidylate synthase and E2F-1 in gefitinib-resistant NSCLC cells with MET amplification but not in those harboring the T790M mutation of EGFR. The combination of 5-fluorouracil and gefitinib synergistically inhibited the proliferation of cells with MET amplification, but not that of those with the T790M mutation of EGFR, in vitro.
& e' l, m+ S5 }7 j$ S! j9 I是不是说因C-MET引起的耐药中,吉非替尼会引导TS低表达3 o! d; G; v9 a' V: m* K$ L
这样是不是推理出,耐药后,可以用S-1和培美了?$ G/ r0 J% B5 B6 F; } ^8 b
结论:
: `+ x" u: _# w; f8 i如果是T790M突变引起的耐药,则2992有效,如果是C-MET扩增引起的突变,则除了184,还可以特+S1联用,而且可能可以用培美。 |