发给老马备查:
! W0 Z$ A: q1 R; j+ p6 _6 d滴水察海(69304838) 15:23:23( _4 M) e6 ~3 P# ], `
老马,我看到培美和S-1都提到TS低表达,而鳞多半不是低表达,是不是S-1不靠谱
% W, _2 P: t8 o9 `$ Y9 G吉非替尼和S-1连用的依据
5 D: i3 v; t( w( p+ ZGefitinib induced down-regulation of thymidylate synthase and E2F-1 in gefitinib-resistant NSCLC cells with MET amplification but not in those harboring the T790M mutation of EGFR. The combination of 5-fluorouracil and gefitinib synergistically inhibited the proliferation of cells with MET amplification, but not that of those with the T790M mutation of EGFR, in vitro.) O' L9 V# {. i0 g1 F
是不是说因C-MET引起的耐药中,吉非替尼会引导TS低表达
2 o8 V/ K0 A# O; Y/ n# m W这样是不是推理出,耐药后,可以用S-1和培美了?+ c. g1 B q2 [3 _2 ~9 R
结论:
; ~% I: K! v: W/ |0 ?( i2 M" f$ _如果是T790M突变引起的耐药,则2992有效,如果是C-MET扩增引起的突变,则除了184,还可以特+S1联用,而且可能可以用培美。 |