发给老马备查:4 W6 r3 G+ g$ I
滴水察海(69304838) 15:23:23
1 s3 o- K4 b& U老马,我看到培美和S-1都提到TS低表达,而鳞多半不是低表达,是不是S-1不靠谱2 s' F. J1 [1 T" N
吉非替尼和S-1连用的依据6 }' l4 S+ v& m+ E; q
Gefitinib induced down-regulation of thymidylate synthase and E2F-1 in gefitinib-resistant NSCLC cells with MET amplification but not in those harboring the T790M mutation of EGFR. The combination of 5-fluorouracil and gefitinib synergistically inhibited the proliferation of cells with MET amplification, but not that of those with the T790M mutation of EGFR, in vitro.
8 l0 p, M- M8 C! y- w( y1 C1 ]是不是说因C-MET引起的耐药中,吉非替尼会引导TS低表达# S" W* `6 I& @& x% M! @5 g
这样是不是推理出,耐药后,可以用S-1和培美了?+ H3 [; Y- k) _3 E* }8 F( K& J
结论:
6 z! g; o1 R5 j7 A" g& B% d) H如果是T790M突变引起的耐药,则2992有效,如果是C-MET扩增引起的突变,则除了184,还可以特+S1联用,而且可能可以用培美。 |